We tested the hypothesis that the stretch-activated, four-transmembrane domain, two pore potassium channels K2P , TREK-1 and TRAAK are gestationally-regulated in human myometrium and contribute to uterine relaxation during pregnancy until labor. We determined the gene and protein expression of K2P channels in non-pregnant, pregnant term and preterm laboring myometrium. We employed both molecular biological and functional studies of K2P channels in myometrial samples taken from women undergoing cesarean delivery of a fetus. Blockade of stretch-activated channels with a channel non-specific tarantula toxin GsMTx-4 or the more specific TREK-1 antagonist L-methionine ethyl ester altered contractile frequency in a dose-dependent manner in pregnant myometrium. Arachidonic acid treatment lowered contractile tension an effect blocked by fluphenazine.
Prenatal Testing Basics: Contraction Stress Test
Reactive Non Stress Test (NST) During Pregnancy
Gap junctions increase in size and abundance coincident with parturition, forming an intercellular communication network that permits the uterus to develop the forceful, coordinated contractions necessary for delivery of the fetus. Lindane, a pesticide used in the human and veterinary treatment of scabies and lice as well as in agricultural applications, inhibits uterine contractions in vitro, inhibits myometrial gap junctions, and has been associated with prolonged gestation length in rats. The aim of the present study was to investigate whether brief exposures to lindane would elicit sustained inhibition of rat uterine contractile activity and myometrial gap junction intercellular communication. To examine effects on uterine contraction, longitudinal uterine strips isolated from late gestation day 20 rats were exposed to lindane in muscle baths and monitored for changes in spontaneous phasic contractions during and after exposure to lindane. Lucifer yellow dye transfer between myometrial cells in culture was used to monitor gap junction intercellular communication.
Reactive Non Stress Test During Pregnancy
Throughout the text are features that help students develop critical thinking skills and apply content to practice—such as nursing procedures, nursing care plans, clinical pearls, patients' and caregivers' stories, critical thinking questions, cultural snapshots, family teaching tips, and over illustrations. Wolters Kluwer Health Bolero Ozon. Introductory Maternity Nursing. Jayne Klossner.
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